PG-ENTRANCE MCQ-test Feb08

01. The common disaccharide, sucrose, contains which of the following monosaccharide residues?

A.      glucose and galactose

B.      glucose and mannose

C.      glucose and fructose

D.      glucose only

E.      mannose and galactose

 

02. Three functions of proteins in the tissues are:

A.      in water balance, as antibodies, and as enzymes.

B.      In the structure of heme, as vitamin and as enzymes.

C.      as enzymes, in acid/base balance, and in the structure of cholesterol.

D.      as a source of energy, as antibodies, and as bile.

E.      in acid/base balance, as HCl, and as a source of energy.

 

03. Which one of the following statements is false:

A.      The enzymes of the Tricarboxylic Acid Cycle (TCA) are located in the mitochondria

B.       TCA cycle is of no metabolic significance for the oxidation of fatty acids or amino acids

C.       TCA cycle is an oxidative process

D.      Pyruvate is converted to Acetyl-CoA before entering the cycle

E.       The cycle functions irreversibly

04. Dietary protein could provide precursors for the de novo synthesis in humans of all of the following EXCEPT

A.      acetoacetate.

B.      ribose.

C.      uric acid.

D.      linoleic acid.

E.      orotic acid

 

05. Which of the following enzymes is required for the conversion of dietary triacylglycerol into chylomicron triacylglycerol?

A.      Acyl- CoA synthetase

B.      Acyl-CoA: cholesterol acyl transferase

C.      Hormone-sensitive triacylglycerol lipase

D.      Lipoprotein lipase

E.      Lysosomal acid lipase.

 

06. In phenylketonuria, following compounds accumulates in the urine:

A.      valine

B.      leucine

C.      isoleucine

D.      phenylalanine

E.      tyrosine

 

07. The liver is able to carry out the reactions of the urea cycle under normal circumstances, whereas other tissues can not. The ability of the liver to synthesize urea is due to the presence of

A.      carbamoyl phosphate synthetase.

B.      ornithine transcarbamoylase.

C.      argininosuccinate synthetase

D.      argininosuccinate lyase.

E.      arginase.

 

08. The oxidation of methanol in human retina leads directly to the formation of ____, and indirectly to____.

A.      CO₂, pressure buildup.

B.      CO₂ , blindness.

C.      sugars, color blindness.

D.      formaldehyde, stomach upset.

E.      formaldehyde, blindness.

 

09. The chemotherapeutic agent methotrexate (amethopterin) is targeted to which of the following enzymes?

A.      dihydrofolate reductase

B.      hypoxanthine guanine phosphoribosyl transferase

C.      ribonucleotide reductase

D.      carbamoyl phosphate synthetase

E.      glutamine synthetase

 

10. Physiological conditions which promote the synthesis of ketone bodies would also promote the

A.      oxidation of fatty acids in erythrocytes.

B.      oxidation of glucose in adipose tissue.

C.      synthesis of amino acids in liver.

D.      synthesis of fatty acids in liver.

E.      synthesis of glucose in liver.

 

11. Severe Combined Immunodeficiency Syndrome is most often due to a deficiency in

A.      adenosine deaminase.

B.      xanthine oxidase.

C.      ribonucleotide reductase.

D.      thymidylate synthase

E.      hypoxanthine-guanine phosphoribosyl transferase

 

12. The protein that binds and directly reduces the terminal electron acceptor in mitochondrial electron transport is

A.      cytochrome bc1.

B.      cytochrome oxidase.

C.      succinate dehydrogenase.

D.      coenzyme QH2

E.      NADH:Q reductase.

 

13. What is the first product of fatty acid catabolism?

A.      glycerol

B.      pyruvate

C.      acetyl CoA

D.      triglycerides

E.      lactate

14. Which of the following is a major function of magnesium?

A.      Transport of oxygen

B.      Prevention of anaemia

C.      Production of thyroid hormone

D.      Catalyst in energy metabolism

 

15. For normal development of taste bud, a zinc containing polypeptide is necessary:

A.      gustin

B.      sucrase

C.      trehalase

D.      gastrin

E.      lactase

 

16. Gastric peptides formed by pepsin are instrumental in initiating pancreatic phase of protein digestion by stimulating:

A.      cholecystokinin

B.      carboxy peptidase A

C.      trypsin inhibitor

D.      trypsinogen

E.      none of above

 

17. A patient with a PCO2 of 30 and a base deficit of +2 most likely has:

A.      respiratory acidosis

B.      respiratory alkalosis

C.      metabolic acidosis

D.      metabolic alkalosis

 

18. Hyperphosphatemia may occur in all of the following conditions EXCEPT:

A.      bone metastases

B.      hypervitaminosis D

C.      milk-alkali syndrome

D.      acromegaly

E.      vitamin D deficiency

 

19. The drug allopurinol (a purine analog) is beneficial for patients with gout because the drug directly inhibits the enzyme :

A.      hypoxanthine-guanine phosphoribosyltransferase (HGPRT).

B.      phosphoribosylpyrophosphate (PRPP) synthetase.

C.      purine nucleoside phosphorylase.

D.      xanthine oxidase.

E.      inosinicase.

 

20. The dihydrofolate reductase inhibitor methotrexate is an effective anticancer drug because :

A.      conversion of ribonucleoside diphosphates (NDPs) to deoxyribonucleoside diphosphates (dNDPs) is inhibited.

B.      conversion of tetrahydrofolate to N⁵,N¹⁰-methylene-tetrahydrofolate is blocked.

C.      conversion of N⁵,N¹⁰-methylene-tetrahydrofolate to dihydrofolate is blocked.

D.      cell replication is blocked in the absence of thymidine triphosphate.

E.      high levels of N¹⁰-formyl-tetrahydrofolate are toxic to tumor cells.

 

 

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 (Students are request to email answers along with their name, place, and name of institution.  A merit list along with the answers to this test will be posted on March 1, 2008)

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