USMLE-1 MCQ-test Feb08
01. Which of the following statements is FALSE:
The functions of
lipids include:
A.
acting as a storage of metabolic reserves
B.
providing protection for organs such as the kidney
C.
transporting glucose across membranes
D.
preventing water loss through the skin
E.
acting as hormones and vitamins
02. The advantage to the human body to use triglycerides as one form of metabolic
energy is because
A.
direct access to mitochondria in cardiac muscle.
B.
easily transported in blood as a complex with albumin.
C.
fully reduced structure and anhydrous storage in adipose.
D.
immediate precursor of ketone bodies in skeletal muscle.
E.
interconvertability with glucose in liver.
03. A mutation in the gene that encodes procollagen
alpha-2(I) would most likely lead to
A.
defective basement membranes.
B.
hyperextension of joints.
C.
increased bone fragility.
D.
weakened arterial walls.
04. In protein deficiency, water accumulates in the
intracellular spaces, the condition is known as
A.
Marasmus
B.
Edema
C.
Anemia
D.
Kwashiorkor
E.
Spongy disease
05. Which of the following does NOT decrease the rate of
blood coagulation?
A.
Antithrombin III
B.
Heparin
C.
Ethylene diamine tetraacetic acid (EDTA)
D.
Warfarin
E.
Calcium ions
06. A young male patient is taking a prescribed dose of
an anti-malarial drug develops anemia. His red blood cells show an abnormally
high ratio of NADP+/NADPH. He is probably suffering from a deficiency of :
A.
glutathione reductase
B.
glutathione synthetase
C.
glucose 6-phosphate dehydrogenase
D.
Aldolase
E.
lactate dehydrogenase
07. Lactose content of milk for lactose-intolerant people
can be decreased using insolubilized :
A.
beta galactosidase
B.
hexokinase
C.
lactose synthatase
D.
phosphoglucomutase
E.
glucokinase
08. Which of the following statement regarding chylomicrons
is INCORRECT?
A.
are delivered to the liver before any other tissue.
B.
are the lipoproteins with the lowest density.
C.
are made in the small intestine.
D.
have a shell of phospholipid
E.
contain cholesterol esters.
09. In patient with alkaptonuria, which one of the following
enzyme is absent:
A.
homogentisic acid oxidase
B.
tyrosine transaminase
C.
tryptophan hydroxylase
D.
phenylalanine decarboxylase
E.
leucine transaminase
10. A significant and rapid decrease in the concentration of
plasma albumin may be caused by a(n)
A.
essential fatty acid deficiency.
B.
excess of essential amino acids.
C.
protein-energy malnutrition.
D.
specific vitamin deficiency.
E.
specific vitamin excess.
11. A metabolite of which of the following nutrients binds
to proteins in the cell nucleus and regulates gene transcription?
A.
alpha-tocopherol
B.
beta-carotene
C.
biotin
D.
cobalt
E.
linoleate
12. In humans the conversion of ribonucleotides to
deoxyribonucleotides by ribonucleotide reductase requires which of the
following cofactors?
A.
NADH
B.
coenzyme A
C.
pyridoxal phosphate
D.
NADPH
E.
Tetrahydrofolate
13. Dehydration may be ordinarily corrected by parenteral
administration of
A.
soda bicarb
B.
sodium chloride
C.
calcium chloride
D.
zinc chloride
E.
magnesium sulphate
14. Hydroxylapatite, a component of bone, is an important
reservoir of the macrominerals
A.
calcium and chloride.
B.
calcium and phosphorus.
C.
calcium, magnesium, and chloride
D.
potassium and chloride.
E.
sodium, potassium, and chloride
15. If a person had glossitis, cheilosis and cataracts you
might suspect a deficiency of:
A.
niacin
B.
riboflavin
C.
vitaminC
D.
thiamin
E.
pyridoxal phosphate
16. Fatulence after eating leguminous seeds is caused by
inability of human intestinal enzyme to hydrolyse:
A.
raffinose
B.
sucrose
C.
fructose
D.
starch
E.
lactose
17. An increased anion gap is associated with:
A.
diabetic ketoacidosis
B.
diarrhea
C.
respiratory acidosis
D.
respiratory alkalosis
E.
vomiting
18. Characteristic Biochemical finding in Wolman's disease
is:
A.
agammaglobulenemia
B.
increased triglyceride
C.
hyperglycinemia
D.
oroticacidurea
E.
decreased ceruloplasmin
19. A ten year old boy presents with precocious puberty. His
cortisol and aldosterone levels are abnormally low, and ACTH and androgen
levels are abnormally high. His most likely problem is a defect in:
A.
P450 c21 hydroxylase.
B.
17 alpha-hydroxyprogesterone.
C.
the androgen receptor.
D.
LH secretion.
E.
ACTH production.
20. Scurvy is caused by a deficiency of ascorbic acid, a
vitamin required for the reaction catalyzed by which type of enzyme?
A.
Hydrolase
B.
Deamidase
C.
Glycosylase
D.
Hydroxylase
E.
Dehydrogenase
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(Students are request to email answers along with their name, place, and name of
institution. A merit list along with the
answers to this test will be posted on March 1, 2008)
Answer key to USMLE-1 MCQ-test: Jan, 2008