MRCP-1 MCQ-test
Feb08
01. Interactions between cells and the extracellular matrix may
be mediated by
A.
cholesteryl esters.
B.
gangliosides.
C.
monoacylglycerol.
D.
long-chain acyl-CoAs.
E.
primary bile salts.
02. Smokers tend to develop emphysema more readily than non-
smokers. This is due to oxidation of a methionine residue in
A.
elastin.
B.
plumonary collagen
C.
neutrophil elastase
D.
alpha-1-antitrypsin
E.
pancreatic elastase
03. The collagen defect present in scurvy is:
A.
decreased protein stability due to decreased hydroxylation
of proline and lysine residues.
B.
substitution of glycine for proline and lyssine residues in
the collagen sequence.
C.
increased formation of Schiff base crosslinks.
D.
decreased protein stability due to increased glycosylation.
E.
conversion of the collagen helix from a right- to a
left-handed triple supercoil.
04. Which of the following conditions promotes release of
oxygen from hemoglobin?
A.
increased pH
B.
increased CO2
C.
decreased 2,3BPG
D.
all of the above
E.
none of the above
05. Patient having McArdle's disease suffers from painful
muscle cramping after brief exercise. The condition results from a deficiency
in of of the following enzymes in glycogen brekdown:
A.
muscle amylo-1,6-glucosidase activity of the debranching
B.
liver glycogen phosphorylase
C.
muscle 4-a-glucanotransferase actvity of the debranching
enzyme.
D.
liver amylo-1,6-glucosidase activity of the debranching
E.
muscle glycogen phosphorylase
06. In some cases of leukemia, depression of viability of
the tumor can be achieved by intravenous administration of:
A.
strptokinase
B.
papain
C.
asparginase
D.
fucin
E.
chymotrypsin
07. In the treatment of hypercholesterolemia, the rationale
for increased regular exercise is to
A.
decrease the reabsorption of bile acids.
B.
elevate the level of high density lipoproteins.
C.
reduce the binding of ligands to the apo-E receptor.
D.
increase the ratio: total cholesterol/high density
lipoprotein cholesterol
E.
reduce the formation of oxidized low density lipoproteins.
08. Which one of the following amino acids give rise to
alpha keto acids that accumulate in the urine in maple syrup urine disease?:
A.
phenylalanine
B.
valine
C.
lysine
D.
tyrosine
E.
all of above
09. A post-operative patient is in negative nitrogen balance
as long as
A.
the amount of nitrogen ingested equals the amount of
nitrogren excreted in urine, feces, and sweat.
B.
the amount of nitrogen excreted in the urine, feces, and
sweat is less than the amount of nitrogen ingested.
C.
the amount of nitrogen excreted in the urine, feces, and
sweat is greater than the amount of nitrogen ingested.
D.
the patient is fed by parenteral, not oral means
10. some serine proteases are useful in clearing blood clots
that occur in myocardial infarcation EXCEPT:
11. Lesch-Nyhan syndrome is caused by a deficiency in which
of the following?
A.
xanthine oxidase
B.
arginase
C.
hypoxanthine-guanine phosphoribosyl transferase
D.
ribose phosphate pyrophosphokinase
E.
adenosine deaminase
12. Tyrosine would be an essential amino acid in the diet of
a child with
A.
Lesch Nyhan Syndrome.
B.
defective tyrosine aminotransferase.
C.
deficiency of pyridoxine.
D.
classical phenylketonuria.
E.
Galactosemia
13. The source of blood glucose during the early stages of
starvation (i.e. 8 - 24 hours) is primarily:
A.
muscle glycogen
B.
dietary carbohydrates
C.
fatty acids from triacylglycerols in adipose tissue
D.
amino acids from the breakdown of protein
E.
liver glycogen
14. Heart tissue deprived of oxygen due to lung
insufficiency will likely
A.
be unaffected because heart muscle normally undergoes
anaerobic metabolism.
B.
become alkalotic because an insufficient supply of protons
are produced by the mitochondrial electron transport chain.
C.
have an insufficiency of ATP produced by oxidative
phosphorylation.
D.
use free fatty acids to make glucose for glycolysis in order
to maintain ATP levels.
E.
shift from anaerobic to aerobic metabolism.
15. Hepatolenticular degeneration resembling Parkinsion’s
disease is caused due to toxicity of
A.
Calcium
B.
Mangnessium
C.
Zinc
D.
Iron
E.
Chromium
16. The physiological regulation of digestive enzymes
secretion occurs through secretagogues. Secretagogues for salivary amylase is:
A.
acetylcholine
B.
gastrin
C.
secretin
D.
guanylin
E.
none of above
17. A serum sodium value of 115 mEq/liter may be associated
with all of the following conditions EXCEPT:
A.
Addison's disease
B.
Inappropriate antidiuretic hormone
C.
Liver disease
D.
Water deprivation
E.
MSUD
18. Following are common biochemical findings in Wilson's
disease, EXCEPT:
A.
Decreased serum copper
B.
Increased urinary copper
C.
Abnormally high plasma ceruloplasmin
D.
Generalized aminoacidurea
E.
Decreased serum uric acid
19. A dietary deficiency of the
following cofactor can lead to the Wernicke- Korsakoff syndrome.
A. biotin
B.
lipoic acid
C.
riboflavin
D.
thiamine
E.
nicacin
20. Barbiturates
such as amytal disrupt energy metabolism by inhibiting the exit of electrons from
complex I. This directly blocks the
A.
conversion of NADH to NAD+.
B.
oxidation of CoQH2 by complex III.
C.
reduction of oxygen by complex IV.
D.
oxidation of cytochrome c by cytochrome oxidase.
E.
electron transfer from FADH2 in complex II to CoQ.
Answer This MCQ test
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(Students are request to email answers along with their name, place, and name of
institution. A merit list along with
the answers to this test will be posted on March 1, 2008)
Answer key to MRCP-1 MCQ-test: Jan, 2008